Chapter 6: Tissue acquisition

EUS has become an essential tool for obtaining tissue samples from a wide range of structures within and around the gastrointestinal tract. Lesions in both the mediastinum and abdomen, can be safely and accurately accessed for biopsy with EUS.

In recent years, fine-needle biopsy (FNB) has largely replaced fine-needle aspiration (FNA) as the preferred technique, thanks to its improved ability to retrieve core tissue samples for histological analysis. Several factors influence the quality of tissue acquisition, including the choice of suction technique (vacuum or slow-pull), the number of needle passes, and other procedural refinements.

This module will walk you through the key principles and practical tips for optimizing tissue acquisition during EUS-guided sampling.